Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC2323581 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Li Yonghong Y Rowland Charles C Catanese Joseph J Morris John J Lovestone Simon S O'Donovan Michael C MC Goate Alison A Owen Michael M Williams Julie J Grupe Andrew A
Neurobiology of disease 20070916 2
A recent study reported significant association of late-onset Alzheimer's disease (LOAD) with multiple single nucleotide polymorphisms (SNPs) and haplotypes in SORL1, a neuronal sortilin-related receptor protein known to be involved in the trafficking and processing of amyloid precursor protein. Here we attempted to validate this finding in three large, well characterized case-control series. Approximately 2000 samples from the three series were individually genotyped for 12 SNPs, including the ...[more]