Ontology highlight
ABSTRACT:
SUBMITTER: Clark SG
PROVIDER: S-EPMC23381 | biostudies-literature | 1997 Sep
REPOSITORIES: biostudies-literature
Clark S G SG Shurland D L DL Meyerowitz E M EM Bargmann C I CI van der Bliek A M AM
Proceedings of the National Academy of Sciences of the United States of America 19970901 19
Drosophila shibire and its mammalian homologue dynamin regulate an early step in endocytosis. We identified a Caenorhabditis elegans dynamin gene, dyn-1, based upon hybridization to the Drosophila gene. The dyn-1 RNA transcripts are trans-spliced to the spliced leader 1 and undergo alternative splicing to code for either an 830- or 838-amino acid protein. These dyn-1 proteins are highly similar in amino acid sequence, structure, and size to the Drosophila and mammalian dynamins: they contain an ...[more]