Ontology highlight
ABSTRACT:
SUBMITTER: Brych SR
PROVIDER: S-EPMC2366980 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Brych Stephen R SR Kim Jaewon J Logan Timothy M TM Blaber Michael M
Protein science : a publication of the Protein Society 20031201 12
An alternative core packing group, involving a set of five positions, has been introduced into human acidic FGF-1. This alternative group was designed so as to constrain the primary structure within the core region to the same threefold symmetry present in the tertiary structure of the protein fold (the beta-trefoil superfold). The alternative core is essentially indistinguishable from the WT core with regard to structure, stability, and folding kinetics. The results show that the beta-trefoil s ...[more]