Ontology highlight
ABSTRACT:
SUBMITTER: Lin DH
PROVIDER: S-EPMC5207208 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160414 6283
The nuclear pore complex (NPC) controls the transport of macromolecules between the nucleus and cytoplasm, but its molecular architecture has thus far remained poorly defined. We biochemically reconstituted NPC core protomers and elucidated the underlying protein-protein interaction network. Flexible linker sequences, rather than interactions between the structured core scaffold nucleoporins, mediate the assembly of the inner ring complex and its attachment to the NPC coat. X-ray crystallographi ...[more]