Ontology highlight
ABSTRACT:
SUBMITTER: Moore JK
PROVIDER: S-EPMC2367371 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Moore Jeffrey K JK Li Jun J Cooper John A JA
Traffic (Copenhagen, Denmark) 20080122 4
Dynactin is a multisubunit protein complex necessary for dynein function. Here, we investigated the function of dynactin in budding yeast. Loss of dynactin impaired movement and positioning of the mitotic spindle, similar to loss of dynein. Dynactin subunits required for function included p150(Glued), dynamitin, actin-related protein (Arp) 1 and p24. Arp10 and capping protein were dispensable, even in combination. All dynactin subunits tested localized to dynamic plus ends of cytoplasmic microtu ...[more]