Ontology highlight
ABSTRACT:
SUBMITTER: Baeyens KJ
PROVIDER: S-EPMC24009 | biostudies-literature | 1996 Nov
REPOSITORIES: biostudies-literature
Baeyens K J KJ De Bondt H L HL Pardi A A Holbrook S R SR
Proceedings of the National Academy of Sciences of the United States of America 19961101 23
The crystal structure of the RNA dodecamer 5'-GGCC(GAAA)GGCC-3' has been determined from x-ray diffraction data to 2.3-A resolution. In the crystal, these oligomers form double helices around twofold symmetry axes. Four consecutive non-Watson-Crick base pairs make up an internal loop in the middle of the duplex, including sheared G.A pairs and novel asymmetric A.A pairs. This internal loop sequence produces a significant curvature and narrowing of the double helix. The helix is curved by 34 degr ...[more]