Ontology highlight
ABSTRACT:
SUBMITTER: Teichmann M
PROVIDER: S-EPMC24131 | biostudies-literature | 1999 Nov
REPOSITORIES: biostudies-literature
Teichmann M M Wang Z Z Martinez E E Tjernberg A A Zhang D D Vollmer F F Chait B T BT Roeder R G RG
Proceedings of the National Academy of Sciences of the United States of America 19991101 24
The TATA-binding protein (TBP)-related factor TRF1, has been described in Drosophila and a related protein, TRF2, has been found in a variety of higher eukaryotes. We report that human (h)TRF2 is encoded by two mRNAs with common protein coding but distinct 5' nontranslated regions. One mRNA is expressed ubiquitously (hTRF2-mRNA1), whereas the other (hTRF2-mRNA2) shows a restricted expression pattern and is extremely abundant in testis. In addition, we show that hTRF2 forms a stable stoichiometri ...[more]