Ontology highlight
ABSTRACT:
SUBMITTER: Kosa PF
PROVIDER: S-EPMC20997 | biostudies-literature | 1997 Jun
REPOSITORIES: biostudies-literature
Kosa P F PF Ghosh G G DeDecker B S BS Sigler P B PB
Proceedings of the National Academy of Sciences of the United States of America 19970601 12
Archaea possess a basal transcriptional apparatus that resembles that of eukaryotes. Here we report the 2.1-A crystal structure of the archaeal transcription factor complex formed by the TATA-box-binding protein (TBP), the transcription factor IIB homolog, and a DNA target, all from the hyperthermophile Pyrococcus woesei. The overall fold of these two basal transcription factors is essentially the same as that of their eukaryotic counterparts. However, in comparison with the eukaryotic complexes ...[more]