Ontology highlight
ABSTRACT:
SUBMITTER: Ruan JP
PROVIDER: S-EPMC522245 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Ruan Jia-Peng JP Arhin George K GK Ullu Elisabetta E Tschudi Christian C
Molecular and cellular biology 20041101 21
Transcriptional mechanisms remain poorly understood in trypanosomatid protozoa. In particular, there is no knowledge about the function of basal transcription factors, and there is an apparent rarity of promoters for protein-coding genes transcribed by RNA polymerase (Pol) II. Here we describe a Trypanosoma brucei factor related to the TATA-binding protein (TBP). Although this TBP-related factor (TBP-related factor 4 [TRF4]) has about 31% identity to the TBP core domain, several key residues inv ...[more]