Apoptosis induced by aminoglycosides in LLC-PK1 Cells: comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation.
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ABSTRACT:
SUBMITTER: Denamur S
PROVIDER: S-EPMC2415793 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
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Apoptosis induced by aminoglycosides in LLC-PK1 Cells: comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation.
Denamur Sophie S Van Bambeke Françoise F Mingeot-Leclercq Marie-Paule MP Tulkens Paul M PM
Antimicrobial agents and chemotherapy 20080407 6
Levels of apoptosis induction (4',6'-diamidino-2-phenylindole staining, activation of caspase 3) for aminoglycosides were compared by using renal LLC-PK1 cells. Amikacin caused less apoptosis than gentamicin in incubated cells. In electroporated cells, neomycin B and gentamicin caused apoptosis in the 0.03 to 0.1 mM range, isepamicin required larger concentrations (0.2 mM), and amikacin was without effect. ...[more]
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2020-03-01 | GSE110832 | GEO