Unknown

Dataset Information

0

Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria.


ABSTRACT: Unobstructed vision requires a particular refractive index of the lens, a measure based on the organization of the structural proteins within the differentiated lens cells. To ensure an intact lens structure, homeostasis within the lens cells is indispensable. Alterations of the lens structure result in opacity and lead to cataract. Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. In a Swiss family with autosomal dominant juvenile cataract, microcornea, and renal glucosuria, we have identified a nonsense mutation in a member of the carboxylic acid transporter family SLC16. The underlying gene defect in SLC16A12 resides within a 3 cM region on chromosome 10q23.13 defined by linkage mapping of this phenotype. We found tissue-specific variability of SLC16A12 transcript levels in control samples, with high expression in the eye and kidney, the two organs affected by this syndrome. This report demonstrates biological relevance of this solute carrier. We hypothesize that SLC16A12 is important for lens and kidney homeostasis and discuss its potential role in age-related cataract.

SUBMITTER: Kloeckener-Gruissem B 

PROVIDER: S-EPMC2427214 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria.

Kloeckener-Gruissem Barbara B   Vandekerckhove Kristof K   Nürnberg Gudrun G   Neidhardt John J   Zeitz Christina C   Nürnberg Peter P   Schipper Isaak I   Berger Wolfgang W  

American journal of human genetics 20080214 3


Unobstructed vision requires a particular refractive index of the lens, a measure based on the organization of the structural proteins within the differentiated lens cells. To ensure an intact lens structure, homeostasis within the lens cells is indispensable. Alterations of the lens structure result in opacity and lead to cataract. Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. In a Swiss family wit  ...[more]

Similar Datasets

| S-EPMC3176021 | biostudies-literature
| S-EPMC2890555 | biostudies-literature
| S-EPMC7232273 | biostudies-literature
| S-EPMC2927419 | biostudies-literature
| S-EPMC4950299 | biostudies-literature
| S-EPMC2690964 | biostudies-literature
| S-EPMC3175982 | biostudies-literature
| S-EPMC2875257 | biostudies-literature
| S-EPMC4438413 | biostudies-literature
| S-EPMC3087119 | biostudies-literature