Ontology highlight
ABSTRACT:
SUBMITTER: Kovanen PE
PROVIDER: S-EPMC2427334 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Kovanen Panu E PE Bernard Jérôme J Al-Shami Amin A Liu Chengyu C Bollenbacher-Reilley Julie J Young Lynn L Pise-Masison Cynthia C Spolski Rosanne R Leonard Warren J WJ
The Journal of biological chemistry 20080421 25
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte proliferation and peripheral tolerance. IL-2 activates mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase, and signal transducer and activator of transcription (STAT) pathways and modulates expression of target genes. Systematic analysis of IL-2 target genes has revealed regulation of potential feedback inhibitors of IL-2 signaling, including several suppressor of cytokine signaling (SOCS) family members ...[more]