Ontology highlight
ABSTRACT:
SUBMITTER: Kutty RG
PROVIDER: S-EPMC5147890 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kutty Raman G RG Xin Gang G Schauder David M DM Cossette Stephanie M SM Bordas Michelle M Cui Weiguo W Ramchandran Ramani R
PloS one 20161209 12
The mitogen-activated protein kinase (MAPK) pathway regulates many key cellular processes such as differentiation, apoptosis, and survival. The final proteins in this pathway, ERK1/2, are regulated by dual specificity phosphatase 5 (DUSP5). DUSP5 is a nuclear, inducible phosphatase with high affinity and fidelity for ERK1/2. By regulating the final step in the MAPK signaling cascade, DUSP5 exerts strong regulatory control over a central cellular pathway. Like other DUSPs, DUSP5 plays an importan ...[more]