Ontology highlight
ABSTRACT:
SUBMITTER: Upton JW
PROVIDER: S-EPMC2427362 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Upton Jason W JW Kaiser William J WJ Mocarski Edward S ES
The Journal of biological chemistry 20080428 25
Herpesviruses such as cytomegaloviruses encode functions that modulate the innate response in diverse ways to counteract host sensing and delay host clearance during infection. The murine cytomegalovirus M45 protein interacts with receptor-interacting protein (RIP) 1 and RIP3 via a RIP homotypic interaction motif. Cell death suppression by M45 requires RIP homotypic interaction motif-dependent interaction with RIP1. This interaction also underlies the cell tropism role of M45 in preventing prema ...[more]