Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC2430758 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Xu Xinran X Gammon Marilie D MD Zeisel Steven H SH Lee Yin Leng YL Wetmur James G JG Teitelbaum Susan L SL Bradshaw Patrick T PT Neugut Alfred I AI Santella Regina M RM Chen Jia J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080129 6
Choline is an essential nutrient required for methyl group metabolism, but its role in carcinogenesis and tumor progression is not well understood. By utilizing a population-based study of 1508 cases and 1556 controls, we investigated the associations of dietary intake of choline and two related micronutrients, methionine and betaine, and risk of breast cancer. The highest quintile of choline consumption was associated with a lower risk of breast cancer [odds ratio (OR): 0.76; 95% confidence int ...[more]