Choline metabolism-based molecular diagnosis of cancer: an update.
Ontology highlight
ABSTRACT:
SUBMITTER: Glunde K
PROVIDER: S-EPMC4871254 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Publications
Choline metabolism-based molecular diagnosis of cancer: an update.
Glunde Kristine K Penet Marie-France MF Jiang Lu L Jacobs Michael A MA Bhujwalla Zaver M ZM
Expert review of molecular diagnostics 20150428 6
Abnormal choline metabolism continues to be identified in multiple cancers. Molecular causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine kinase-α, phosphatidylcholine-specific phospholipase C and -D and glycerophosphocholine phosphodiesterases, as well as several choline transporters. The net outcome of these enzymatic changes is an increase in phosphocholine and total choline (tCho) and, in some cancers, a relative decrease of glycerophosphocholine. The increase ...[more]
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