Ontology highlight
ABSTRACT:
SUBMITTER: Erickson JR
PROVIDER: S-EPMC2435269 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Erickson Jeffrey R JR Joiner Mei-ling A ML Guan Xiaoqun X Kutschke William W Yang Jinying J Oddis Carmine V CV Bartlett Ryan K RK Lowe John S JS O'Donnell Susan E SE Aykin-Burns Nukhet N Zimmerman Matthew C MC Zimmerman Kathy K Ham Amy-Joan L AJ Weiss Robert M RM Spitz Douglas R DR Shea Madeline A MA Colbran Roger J RJ Mohler Peter J PJ Anderson Mark E ME
Cell 20080501 3
Calcium/calmodulin (Ca2+/CaM)-dependent protein kinase II (CaMKII) couples increases in cellular Ca2+ to fundamental responses in excitable cells. CaMKII was identified over 20 years ago by activation dependence on Ca2+/CaM, but recent evidence shows that CaMKII activity is also enhanced by pro-oxidant conditions. Here we show that oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM. CaMKII is activated by angiotensin II (AngII)-induced o ...[more]