Drug-sensitive FGFR2 mutations in endometrial carcinoma.
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ABSTRACT:
SUBMITTER: Dutt A
PROVIDER: S-EPMC2438391 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Publications
Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Dutt Amit A Salvesen Helga B HB Chen Tzu-Hsiu TH Ramos Alex H AH Onofrio Robert C RC Hatton Charlie C Nicoletti Richard R Winckler Wendy W Grewal Rupinder R Hanna Megan M Wyhs Nicolas N Ziaugra Liuda L Richter Daniel J DJ Trovik Jone J Engelsen Ingeborg B IB Stefansson Ingunn M IM Fennell Tim T Cibulskis Kristian K Zody Michael C MC Akslen Lars A LA Gabriel Stacey S Wong Kwok-Kin KK Sellers William R WR Meyerson Matthew M Greulich Heidi H
Proceedings of the National Academy of Sciences of the United States of America 20080613 25
Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2, are present in 12% of endometrial carcinomas, with additional instances found in lung squamous cell carcinoma and cervical carcinoma. These FGFR2 mutations, many of which are identical to mutations associate ...[more]
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