Ontology highlight
ABSTRACT:
SUBMITTER: Liao RG
PROVIDER: S-EPMC3749739 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Liao Rachel G RG Jung Joonil J Tchaicha Jeremy J Wilkerson Matthew D MD Sivachenko Andrey A Beauchamp Ellen M EM Liu Qingsong Q Pugh Trevor J TJ Pedamallu Chandra Sekhar CS Hayes D Neil DN Gray Nathanael S NS Getz Gad G Wong Kwok-Kin KK Haddad Robert I RI Meyerson Matthew M Hammerman Peter S PS
Cancer research 20130620 16
A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung SCC) has recently been reported, enabling the identification of genomic events that contribute to the oncogenesis of this disease. In lung SCC, one of the most frequently altered receptor tyrosine kinase families is the fibroblast growth factor receptor (FGFR) family, with amplification or mutation observed in all four family members. Here, we describe the oncogenic nature of mutations observed in FGFR2 and ...[more]