Ontology highlight
ABSTRACT:
SUBMITTER: Ducat D
PROVIDER: S-EPMC2441676 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20080507 7
To identify novel proteins important for microtubule assembly in mitosis, we have used a centrosome-based complementation assay to enrich for proteins with mitotic functions. An RNA interference (RNAi)-based screen of these proteins allowed us to uncover 13 novel mitotic regulators. We carried out in-depth analyses of one of these proteins, Pontin, which is known to have several functions in interphase, including chromatin remodeling, DNA repair, and transcription. We show that reduction of Pont ...[more]