Ontology highlight
ABSTRACT:
SUBMITTER: Sarker KP
PROVIDER: S-EPMC2442333 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Sarker Krishna P KP Kataoka Hiromi H Chan Angela A Netherton Stuart J SJ Pot Isabelle I Huynh Mai Anh MA Feng Xiaolan X Bonni Azad A Riabowol Karl K Bonni Shirin S
The Journal of biological chemistry 20080311 19
Members of the ING (inhibitor of growth) family of chromatin modifying proteins (ING1-ING5) have emerged as critical regulators of gene expression and cellular responses, suggesting that the ING proteins may impinge on specific signal transduction pathways and their mediated effects. Here, we demonstrate a role for the protein ING2 in mediating responses by the transforming growth factor (TGF)-beta-Smad signaling pathway. We show that ING2 promotes TGF-beta-induced transcription. Both gain-of-fu ...[more]