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ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells.


ABSTRACT: Members of the ING (inhibitor of growth) family of chromatin modifying proteins (ING1-ING5) have emerged as critical regulators of gene expression and cellular responses, suggesting that the ING proteins may impinge on specific signal transduction pathways and their mediated effects. Here, we demonstrate a role for the protein ING2 in mediating responses by the transforming growth factor (TGF)-beta-Smad signaling pathway. We show that ING2 promotes TGF-beta-induced transcription. Both gain-of-function and RNA interference-mediated knockdown of endogenous ING2 reveal that ING2 couples TGF-beta signals to the induction of transcription and cell cycle arrest. We also find that the Smad-interacting transcriptional modulator SnoN interacts with ING2 and promotes the assembly of a protein complex containing SnoN, ING2, and Smad2. Knockdown of endogenous SnoN blocks the ability of ING2 to promote TGF-beta-dependent transcription, and conversely expression of SnoN augments ING2 enhancement of the TGF-beta response. Collectively, our data suggest that ING2 collaborates with SnoN to mediate TGF-beta-induced Smad-dependent transcription and cellular responses.

SUBMITTER: Sarker KP 

PROVIDER: S-EPMC2442333 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature

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ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells.

Sarker Krishna P KP   Kataoka Hiromi H   Chan Angela A   Netherton Stuart J SJ   Pot Isabelle I   Huynh Mai Anh MA   Feng Xiaolan X   Bonni Azad A   Riabowol Karl K   Bonni Shirin S  

The Journal of biological chemistry 20080311 19


Members of the ING (inhibitor of growth) family of chromatin modifying proteins (ING1-ING5) have emerged as critical regulators of gene expression and cellular responses, suggesting that the ING proteins may impinge on specific signal transduction pathways and their mediated effects. Here, we demonstrate a role for the protein ING2 in mediating responses by the transforming growth factor (TGF)-beta-Smad signaling pathway. We show that ING2 promotes TGF-beta-induced transcription. Both gain-of-fu  ...[more]

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