Ontology highlight
ABSTRACT:
SUBMITTER: Ye Y
PROVIDER: S-EPMC2442819 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Ye Yu Y Muller James G JG Burrows Cynthia J CJ
The Journal of organic chemistry 20060301 5
Two convenient synthetic routes to the oxidized guanosine triphosphate lesions spiroiminodihydantoin-2'-deoxynucleoside-5'-triphosphate (dSpTP) and guanidinohydantoin-2'-deoxynucleoside-5'-triphosphate (dGhTP) are reported. Both two-electron oxidation of 2'-deoxy-7,8-dihydro-8-oxoguanosine-5'-triphosphate (dOGTP) using SO4*- generated photolytically from K2S2O8 or four-electron oxidation of 2'-deoxyguanosine-5'-triphosphate (dGTP) from singlet oxygen provide either dSpTP or dGhTP at pH 8.0 or 4. ...[more]