Ontology highlight
ABSTRACT:
SUBMITTER: Wolter S
PROVIDER: S-EPMC2447141 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Wolter Sabine S Doerrie Anneke A Weber Axel A Schneider Heike H Hoffmann Elke E von der Ohe Juliane J Bakiri Latifa L Wagner Erwin F EF Resch Klaus K Kracht Michael M
Molecular and cellular biology 20080428 13
Interleukin-1 (IL-1)-induced mRNA expression of ccl2 (also called MCP-1), a prototypic highly regulated inflammatory gene, is severely suppressed in cells lacking c-Jun or Jun N-terminal protein kinase 1 (JNK1)/JNK2 genes and is only partially restored in cells expressing a c-Jun(SS63/73AA) mutant protein. We used chromatin immunoprecipitation to identify three c-Jun-binding sites located in the far 5' region close to the transcriptional start site and in the far 3' region of murine and human cc ...[more]