Unknown

Dataset Information

0

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.

ABSTRACT: Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC2447655 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.

Zhang Huafeng H   Bosch-Marce Marta M   Shimoda Larissa A LA   Tan Yee Sun YS   Baek Jin Hyen JH   Wesley Jacob B JB   Gonzalez Frank J FJ   Semenza Gregg L GL  

The Journal of biological chemistry 20080215 16

Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondr  ...[more]