Ontology highlight
ABSTRACT:
SUBMITTER: Leiherer A
PROVIDER: S-EPMC3969228 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Leiherer Andreas A Geiger Kathrin K Muendlein Axel A Drexel Heinz H
Molecular and cellular endocrinology 20131122 1-2
To elucidate the complex impact of hypoxia on adipose tissue, resulting in biased metabolism, insulin resistance and finally diabetes we used mature adipocytes derived from a Simpson-Golabi-Behmel syndrome patient for microarray analysis. We found a significantly increased transcription rate of genes involved in glycolysis and a striking association between the pattern of upregulated genes and disease biomarkers for diabetes mellitus and insulin resistance. Although their upregulation turned out ...[more]