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Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).

ABSTRACT: Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active.

SUBMITTER: Cao S

PROVIDER: S-EPMC2464365 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).

Cao Shugeng S Brodie Peggy J PJ Miller James S JS Ratovoson Fidy F Callmander Martin W MW Randrianasolo Sennen S Rakotobe Etienne E Rasamison Vincent E VE Suh Edward M EM TenDyke Karen K Kingston David G I DG

Journal of natural products 20070605 6

Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 ...[more]

PMID: 17547460

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