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Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest.

ABSTRACT: Bioassay-guided fractionation of the EtOH extracts obtained from a plant identified as Didymochlaena truncatula led to the isolation of two cytotoxic alkaloids, camptothecin and 9-methoxycamptothecin. A second plant collection yielded three lignan derivatives, didymochlaenone A (1), didymochlaenone B (2), and (-)-wikstromol, one stilbene, (E)-3-methoxy-5-hydroxystilbene, and two stigmasterol derivatives, stigmast-4-en-3beta-ol and stigmast-4-en-3-one, but no camptothecins, and it is probable that a coding error led to a mistaken identification of the original extract. The structures of the new compounds 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data.

SUBMITTER: Cao S

PROVIDER: S-EPMC2442717 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest.

Cao Shugeng S Radwan Mohamed M MM Norris Andrew A Miller James S JS Ratovoson Fidy F Mamisoa Andrianjafy A Andriantsiferana Rabodo R Rasamison Vincent E VE Rakotonandrasana Stephan S Kingston David G I DG

Journal of natural products 20060201 2

Bioassay-guided fractionation of the EtOH extracts obtained from a plant identified as Didymochlaena truncatula led to the isolation of two cytotoxic alkaloids, camptothecin and 9-methoxycamptothecin. A second plant collection yielded three lignan derivatives, didymochlaenone A (1), didymochlaenone B (2), and (-)-wikstromol, one stilbene, (E)-3-methoxy-5-hydroxystilbene, and two stigmasterol derivatives, stigmast-4-en-3beta-ol and stigmast-4-en-3-one, but no camptothecins, and it is probable tha ...[more]

PMID: 16499333

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