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Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

ABSTRACT: Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3',4'-deoxy-4'-chloropsoroxanthin-(3',5'-diol) ( 1) and psoroxanthin ( 4), were determined on the basis of 2D-NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line).

SUBMITTER: Leet JE

PROVIDER: S-EPMC2930019 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

Leet John E JE Liu Xiaohong X Drexler Dieter M DM Cantone Joseph L JL Huang Stella S Mamber Stephen W SW Fairchild Craig R CR Hussain Raouf R Newman David J DJ Kingston David G I DG

Journal of natural products 20080205 3

Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3',4'-deoxy-4'-chloropsoroxanthin-(3',5'-diol) ( 1) and psoroxanthin ( 4), were determined on the basis of 2D-NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new ...[more]

PMID: 18247570

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