Ontology highlight
ABSTRACT:
SUBMITTER: Chin YW
PROVIDER: S-EPMC2471879 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Chin Young-Won YW Mdee Ladislaus K LK Mbwambo Zakaria H ZH Mi Qiuwen Q Chai Hee-Byung HB Cragg Gordon M GM Swanson Steven M SM Kinghorn A Douglas AD
Journal of natural products 20061101 11
Five new prenylated flavonoids (1-5) were isolated from the root bark of Berchemia discolor, collected in Tanzania, along with 10 known compounds, by bioactivity-guided fractionation. The structures of compounds 1-5 were elucidated using various spectroscopic techniques. Of these isolates, compound 4, and the known compounds nitidulin (6), amorphigenin (7), and dabinol (8), exhibited cytotoxic activity when evaluated against a small panel of human cancer cells. Nitidulin (6) was further tested i ...[more]