Ontology highlight
ABSTRACT:
SUBMITTER: Hahn CK
PROVIDER: S-EPMC2474517 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Hahn Cynthia K CK Ross Kenneth N KN Warrington Ian M IM Mazitschek Ralph R Kanegai Cindy M CM Wright Renee D RD Kung Andrew L AL Golub Todd R TR Stegmaier Kimberly K
Proceedings of the National Academy of Sciences of the United States of America 20080707 28
The discovery of new small molecules and their testing in rational combination poses an ongoing problem for rare diseases, in particular, for pediatric cancers such as neuroblastoma. Despite maximal cytotoxic therapy with double autologous stem cell transplantation, outcome remains poor for children with high-stage disease. Because differentiation is aberrant in this malignancy, compounds that modulate transcription, such as histone deacetylase (HDAC) inhibitors, are of particular interest. Howe ...[more]