Ontology highlight
ABSTRACT:
SUBMITTER: Fdez E
PROVIDER: S-EPMC2488295 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20080528 8
The interactions underlying the cooperativity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes during neurotransmission are not known. Here, we provide a molecular characterization of a dimer formed between the cytoplasmic portions of neuronal SNARE complexes. Dimerization generates a two-winged structure in which the C termini of cytosolic SNARE complexes are in apposition, and it involves residues from the vesicle-associated SNARE synaptobrevin 2 that ...[more]