Ontology highlight
ABSTRACT:
SUBMITTER: Staunton J
PROVIDER: S-EPMC6763921 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201 23
Rabphilin, a putative rab effector, interacts specifically with the GTP-bound form of the synaptic vesicle-associated protein rab3a. In this study, we define in vivo functions for rabphilin through the characterization of mutants that disrupt the Caenorhabditis elegans rabphilin homolog. The mutants do not display the general synaptic defects associated with rab3 lesions, as assayed at the pharmacological, physiological, and ultrastructural level. However, rabphilin mutants exhibit severe lethar ...[more]