Ontology highlight
ABSTRACT:
SUBMITTER: Codding SJ
PROVIDER: S-EPMC4938179 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20160510 28
Resealing of tears in the sarcolemma of myofibers is a necessary step in the repair of muscle tissue. Recent work suggests a critical role for dysferlin in the membrane repair process and that mutations in dysferlin are responsible for limb girdle muscular dystrophy 2B and Miyoshi myopathy. Beyond membrane repair, dysferlin has been linked to SNARE-mediated exocytotic events including cytokine release and acid sphingomyelinase secretion. However, it is unclear whether dysferlin regulates SNARE-m ...[more]