Ontology highlight
ABSTRACT:
SUBMITTER: Leiros HK
PROVIDER: S-EPMC2496872 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Leiros Hanna Kirsti S HK Tedesco Consiglia C McSweeney Seán M SM
Acta crystallographica. Section F, Structural biology and crystallization communications 20080516 Pt 6
Many anaerobic human pathogenic bacteria are treated using 5-nitroimidazole-based (5-Ni) antibiotics, a class of inactive prodrugs that contain a nitro group. The nitro group must be activated in an anaerobic one-electron reduction and is therefore dependent on the redox system in the target cells. Antibiotic resistance towards 5-Ni drugs is found to be related to the nim genes (nimA, nimB, nimC, nimD, nimE and nimF), which are proposed to encode a reductase that is responsible for converting th ...[more]