Ontology highlight
ABSTRACT:
SUBMITTER: Romero FA
PROVIDER: S-EPMC2501112 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20061101 43
The synthesis and examination of a systematic series of 5-substituted 2-keto oxazoles as inhibitors of fatty acid amide hydrolase (FAAH) defined a fundamental substituent effect that led to the discovery of inhibitors with Ki's as low as 400 pM. The intrinsic basis of the relationship (-log Ki vs sigmap), which relates Ki with the Hammett sigmap constant of the substituent, the magnitude of the effect (rho = 3.01), and its predictive value (R2 = 0.91) suggest a widespread applicability in studie ...[more]