Ontology highlight
ABSTRACT:
SUBMITTER: Tan W
PROVIDER: S-EPMC2515565 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Tan Wenbin W Janczewski Wiktor A WA Yang Paul P Shao Xuesi M XM Callaway Edward M EM Feldman Jack L JL
Nature neuroscience 20080406 5
Delineating neurons that underlie complex behaviors is of fundamental interest. Using adeno-associated virus 2, we expressed the Drosophila allatostatin receptor in somatostatin (Sst)-expressing neurons in the preBötzinger Complex (preBötC). Rapid silencing of these neurons in awake rats induced a persistent apnea without any respiratory movements to rescue their breathing. We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal ...[more]