Ontology highlight
ABSTRACT:
SUBMITTER: Tsibris AM
PROVIDER: S-EPMC2519584 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Tsibris Athe M N AM Sagar Manish M Gulick Roy M RM Su Zhaohui Z Hughes Michael M Greaves Wayne W Subramanian Mani M Flexner Charles C Giguel Françoise F Leopold Kay E KE Coakley Eoin E Kuritzkes Daniel R DR
Journal of virology 20080521 16
Little is known about the in vivo development of resistance to human immunodeficiency virus type 1 (HIV-1) CCR5 antagonists. We studied 29 subjects with virologic failure from a phase IIb study of the CCR5 antagonist vicriviroc (VCV) and identified one individual with HIV-1 subtype C who developed VCV resistance. Studies with chimeric envelopes demonstrated that changes within the V3 loop were sufficient to confer VCV resistance. Resistant virus showed VCV-enhanced replication, cross-resistance ...[more]