Ontology highlight
ABSTRACT:
SUBMITTER: Tripathy SK
PROVIDER: S-EPMC2525593 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Tripathy Sandeep K SK Keyel Peter A PA Yang Liping L Pingel Jeanette T JT Cheng Tammy P TP Schneeberger Achim A Yokoyama Wayne M WM
The Journal of experimental medicine 20080707 8
Natural killer (NK) cell tolerance mechanisms are incompletely understood. One possibility is that they possess self-specific activation receptors that result in hyporesponsiveness unless modulated by self-major histocompatability complex (MHC)-specific inhibitory receptors. As putative self-specific activation receptors have not been well characterized, we studied a transgenic C57BL/6 mouse that ubiquitously expresses m157 (m157-Tg), which is the murine cytomegalovirus (MCMV)-encoded ligand for ...[more]