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Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

ABSTRACT: Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

SUBMITTER: Tipparaju SK

PROVIDER: S-EPMC2526048 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Tipparaju Suresh K SK Joyasawal Sipak S Forrester Sara S Mulhearn Debbie C DC Pegan Scott S Johnson Michael E ME Mesecar Andrew D AD Kozikowski Alan P AP

Bioorganic & medicinal chemistry letters 20080504 12

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR. ...[more]

PMID: 18499454

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Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase.

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Unsaturated fatty acid synthesis in Enterococcus faecalis requires a specific enoyl-ACP reductase.

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Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.

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