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An alpha-formylglycine building block for fmoc-based solid-phase peptide synthesis.

ABSTRACT: [reaction: see text] Nearly all known sulfatases share a common active site modification that is required for their activity: conversion of cysteine to alpha-formylglycine. We report the synthesis of an alpha-formylglycine building block suitable for Fmoc-based solid-phase peptide synthesis. The building block was incorporated into a synthetic peptide derived from the active site of a Mycobacterium tuberculosis sulfatase.

SUBMITTER: Rush J

PROVIDER: S-EPMC2527029 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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An alpha-formylglycine building block for fmoc-based solid-phase peptide synthesis.

Rush Jason J Bertozzi Carolyn R CR

Organic letters 20060101 1

[reaction: see text] Nearly all known sulfatases share a common active site modification that is required for their activity: conversion of cysteine to alpha-formylglycine. We report the synthesis of an alpha-formylglycine building block suitable for Fmoc-based solid-phase peptide synthesis. The building block was incorporated into a synthetic peptide derived from the active site of a Mycobacterium tuberculosis sulfatase. ...[more]

PMID: 16381585

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