Ontology highlight
ABSTRACT:
SUBMITTER: Rush J
PROVIDER: S-EPMC2527029 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Rush Jason J Bertozzi Carolyn R CR
Organic letters 20060101 1
[reaction: see text] Nearly all known sulfatases share a common active site modification that is required for their activity: conversion of cysteine to alpha-formylglycine. We report the synthesis of an alpha-formylglycine building block suitable for Fmoc-based solid-phase peptide synthesis. The building block was incorporated into a synthetic peptide derived from the active site of a Mycobacterium tuberculosis sulfatase. ...[more]