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An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.

ABSTRACT: An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

SUBMITTER: Yoo B

PROVIDER: S-EPMC2702766 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.

Yoo Byunghee B Sheth Vipul R VR Pagel Mark D MD

Tetrahedron letters 20090801 31

An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents. ...[more]

PMID: 20161272

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