Ontology highlight
ABSTRACT:
SUBMITTER: Postma TM
PROVIDER: S-EPMC3971734 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Postma Tobias M TM Albericio Fernando F
Organic letters 20140311 6
Contrary to other studies, here we describe cysteine (Cys) pseudoproline-containing peptides with short deprotection times in TFA. The deprotection times fell in the same range as other protecting groups commonly used in SPPS (e.g., 1-3 h). Moreover, when using Cys pseudoprolines as peptide macrocyclization-enhancing moieties a considerable reduction in reaction time was observed compared to a peptide containing trityl protected Cys. ...[more]