Ontology highlight
ABSTRACT:
SUBMITTER: Thomas D
PROVIDER: S-EPMC2529466 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Thomas Dierk D Plant Leigh D LD Wilkens Christina M CM McCrossan Zoe A ZA Goldstein Steve A N SA
Neuron 20080601 6
K(2P) channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Here, we show that alternative translation initiation (ATI) regulates function of K(2P)2.1 (TREK-1) via an unexpected strategy. Full-length K(2P)2.1 and an isoform lacking the first 56 residues of the intracellular N terminus (K(2P)2.1Delta1-56) are produced differentially in a regional ...[more]