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Kipukasins, nucleoside derivatives from Aspergillus versicolor.


ABSTRACT: Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor. The structures of compounds 1-7 were determined by analysis of NMR and MS data. The nucleoside portion of lead compound 1 was assigned as uracil-1-beta-D-ribofuranoside by spectral comparison with an authentic standard. The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the known metabolite sterigmatocystin, but kipukasins A and B showed modest activity in assays against Gram-positive bacteria.

SUBMITTER: Jiao P 

PROVIDER: S-EPMC2532754 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Kipukasins, nucleoside derivatives from Aspergillus versicolor.

Jiao Ping P   Mudur Sanjay V SV   Gloer James B JB   Wicklow Donald T DT  

Journal of natural products 20070703 8


Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor. The structures of compounds 1-7 were determined by analysis of NMR and MS data. The nucleoside portion of lead compound 1 was assigned as uracil-1-beta-D-ribofuranoside by spectral comparison with an authentic standard. The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the  ...[more]

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