Ontology highlight
ABSTRACT:
SUBMITTER: Chain FJ
PROVIDER: S-EPMC2533705 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Chain Frédéric J J FJ Ilieva Dora D Evans Ben J BJ
PloS one 20080925 9
<h4>Background</h4>Prefabricated expression microarrays are currently available for only a few species but methods have been proposed to extend their application to comparisons between divergent genomes.<h4>Methodology/principal findings</h4>Here we demonstrate that the hybridization intensity of genomic DNA is a poor basis on which to select unbiased probes on Affymetrix expression arrays for studies of comparative transcriptomics, and that doing so produces spurious results. We used the Affyme ...[more]