Ontology highlight
ABSTRACT:
SUBMITTER: Ma S
PROVIDER: S-EPMC6052463 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ma Siming S Avanesov Andrei S AS Porter Emily E Lee Byung Cheon BC Mariotti Marco M Zemskaya Nadezhda N Guigo Roderic R Moskalev Alexey A AA Gladyshev Vadim N VN
Aging cell 20180419 4
Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life-history traits and transcriptomes of 14 Drosophila species differing more than sixfold in lifespan, we explored expression divergence and identified genes and processes that correlate with longevity. These longevity signatures suggested that ...[more]