Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhry P
PROVIDER: S-EPMC2539067 | biostudies-literature | 2007 May-Jun
REPOSITORIES: biostudies-literature
Chaudhry Priyanka P Schoenen Frank F Neuenswander Benjamin B Lushington Gerald H GH Aubé Jeffrey J
Journal of combinatorial chemistry 20070329 3
The reactions of 1,2- and 1,3-hydroxyalkyl azides and aldehydes in the presence of Lewis acid result in the one-step construction of oxazolines and dihydrooxazines, respectively. The reaction was adapted to parallel synthesis using a polymer-bound phosphine to scavenge excess hydroxyalkyl azide. Thus, a 60-member library of various disubstituted oxazolines and di- and trisubstituted dihydrooxazines was generated. ...[more]