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One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes.


ABSTRACT: BACKGROUND:Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lewis or Brønsted acid catalyst, followed by a further reaction with metal salts to obtain the corresponding metal complexes. Very often, the yield afforded by the two-step procedure is not high, and very few oxazolinyl zinc complexes have been prepared by this route. Given that metal-oxazoline complexes often contain Lewis acidic metals, it is conceivable that the two steps may be telescoped. RESULTS:A series of novel chiral organozinc complexes 1-15 were assembled in a single step, All crystalline compounds were fully characterized, including the report of 15 X-ray crystal structures, including a wide structural diversity. CONCLUSIONS:A series of novel chiral organozinc complexes were assembled in a single step, from nitriles, chiral D/L amino alcohols, and a stoichiometric amount of ZnCl2, with moderate to high yields (20-90%).

SUBMITTER: Luo M 

PROVIDER: S-EPMC5549684 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes.

Luo Mei M   Zhang Jing Cheng JC   Pang Wen Min WM   Hii King Kuok KK  

Chemistry Central journal 20170809 1


<h4>Background</h4>Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lewis or Brønsted acid catalyst, followed by a further reaction with metal salts to obtain the corresponding metal complexes. Very often, the yield afforded by the two-step procedure is not high, and very few oxazolinyl zinc complexes have been prepared by this route. Given  ...[more]

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