Ontology highlight
ABSTRACT:
SUBMITTER: Haugland GT
PROVIDER: S-EPMC2553600 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Nucleic acids research 20080830 17
The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea. In most archaeal species studied, the interaction between MCM and the initiator protein, Cdc6, inhibits helicase activity. To date, the only exception is the helicase and Cdc6 proteins from the archaeon Thermoplasma acidophilum. It was previously shown that when the Cdc6 protein interacts with MCM it substantially stimulates helicase activity. It is shown here that the mechanism by whic ...[more]