Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC2562713 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Zhang Yuzhen Y Goss Ashley M AM Cohen Ethan David ED Kadzik Rachel R Lepore John J JJ Muthukumaraswamy Karthika K Yang Jifu J DeMayo Francesco J FJ Whitsett Jeffrey A JA Parmacek Michael S MS Morrisey Edward E EE
Nature genetics 20080608 7
Epithelial organs, including the lung, are known to possess regenerative abilities through activation of endogenous stem cell populations, but the molecular pathways regulating stem cell expansion and regeneration are not well understood. Here we show that Gata6 regulates the temporal appearance and number of bronchioalveolar stem cells (BASCs) in the lung, its absence in Gata6-null lung epithelium leading to the precocious appearance of BASCs and concurrent loss in epithelial differentiation. T ...[more]